Cellular Resistance to Oxaliplatin and Drug Accumulation Defects

摘要: Platinum drugs are employed in a wide range of solid tumors, and represent the mainstay first-line therapy ovarian carcinoma. Although cisplatin has shown efficacy treatment different types tumors including carcinoma, resistance to is major limitation. At present, one most clinically relevant analogues mononuclear compound oxaliplatin, which activity favorable pharmacological profile clinical therapy. In cellular models, oxaliplatin exhibits some cell lines with acquired cisplatin, whereas other models cross-resistance observed. general, exhibit pattern cytotox-icity, indicating differences drug-DNA interaction and/or response or detoxification. Thus, influx efflux mechanisms for these could contribute their unique patterns at least part sensitivity profiles. Impaired drug accumulation been recognized over years as frequent feature cells resistant more recently an alter ation oxaliplatin-resistant models. The present chapter reviews recent studies on molecular alterations particular reference defects will revisit literature attempt describe tentative picture why may display impaired accumulation.