Dynorphin immunoreactive fibers contact GnRH neurons in the human hypothalamus
作者： Stephanie K. Dahl , Marcel Amstalden , Lique Coolen , Maureen Fitzgerald , Michael Lehman
关键词: Gonadotropin-releasing hormone 、 Hypothalamus 、 Immunocytochemistry 、 Neuron 、 Opioid peptide 、 Dynorphin 、 Endogenous opioid 、 Endocrinology 、 Preoptic area 、 Biology 、 Internal medicine
摘要: Dynorphin, an endogenous opioid peptide, mediates progesterone-negative feedback on gonadotropin-releasing hormone (GnRH) neurons in other species. The role of dynorphin humans is unclear. objective this study was to determine if fibers have close contacts with GnRH humans. Dual-label immunocytochemistry performed postmortem human hypothalamic tissue. majority neurons, 87.5%, had and multiple were common, 62.5%. There no regional differences between the hypothalamus preoptic area distribution contacts. More identified dendrites compared cell bodies (P < .001), but difference not significant when corrected for length. In conclusion, form This neuroanatomical evidence may suggest that has effects regulation as seen
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