Bi-and trispecific antibodies for the induction of anti-tumor immunity
作者： Stefan Thierfelder , Horst Lindhofer , Hans-Jochem Kolb
DOI:
关键词: Antitumor immunity 、 T cell 、 Antigen 、 T cell receptor complex 、 Antibody 、 Immunity 、 Bispecific antibody 、 Molecular biology 、 Chemistry 、 Anti-IL-6
摘要: According to the invention, a method is provided wherein intact bispecific or trispecific antibodies which at same time bind T cell receptor complex of cell, tumor-associated antigens on tumor and, via Fc portion antibody, receptor-positive cells are used for induction an anti-tumour immunity in humans and animals.
glgoo.top参考文章(12)
G J Weiner, S A Kostelny, B K Link, J Y Tso, J R Hillstrom, M S Cole, S L Wang, The role of T cell activation in anti-CD3 x antitumor bispecific antibody therapy. Journal of Immunology. ,vol. 152, pp. 2385- 2392 ,(1994)
Michael W. Fanger, Clark L. Anderson, Paul M. Guyre, Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes ,(1987)
Martin Wild, Burkhart Schraven, Wolfgang Strittmatter, Stefan Meuer, Carlota-Siliva Jaggle, Bispecific trigger molecules recognizing lymphocyte antigen cd2 and tumor antigens ,(1994)
Christopher L. Reading, Recombinant monoclonal antibodies ,(1982)
LOUIS M. WEINER, JOSEPH I. CLARK, DAVID B. RING, R. KATHERINE ALPAUGH, Clinical Development of 2B1, a Bispecific Murine Monoclonal Antibody Targeting c-erbB-2 and FcγRIII Journal of hematotherapy. ,vol. 4, pp. 453- 456 ,(1995) , 10.1089/SCD.1.1995.4.453
Lucia M. R. Silla, Jian Chen, Rui-kun Zhong, Theresa L. Whiteside, Edward D. Ball, Potentiation of lysis of leukaemia cells by a bispecific antibody to CD33 and CD16 (FcγRIII) expressed by human natural killer (NK) cells British Journal of Haematology. ,vol. 89, pp. 712- 718 ,(2008) , 10.1111/J.1365-2141.1995.TB08406.X
Edward D. Ball, Jie-Hua Zhou, Jian Chen, Monocyte-mediated lysis of acute myeloid leukemia cells in the presence of the bispecific antibody 251 x 22 (anti-CD33 x anti-CD64). Clinical Cancer Research. ,vol. 1, pp. 1319- 1325 ,(1995)
George J. Weiner, Gijsbert C. De Gast, Bispecific Monoclonal Antibody Therapy of B-Cell Malignancy Leukemia & Lymphoma. ,vol. 16, pp. 199- 207 ,(1995) , 10.3109/10428199509049758
Paul M. Guyre, Michael W. Fanger, Edmund J. Gosselin, Jean Loup Romet-Lemonne, Targeted immunostimulation with bispecific reagents ,(1991)
GIJSBERT C. DE GAST, ANJA A. VAN HOUTEN, INEZ-ANNE HAAGEN, SIGRID KLEIN, ROEL A. DE WEGER, ANET VAN DIJK, JENNY PHILLIPS, MIKE CLARK, BERT J.E.G. BAST, Clinical experience with CD3 x CD19 bispecific antibodies in patients with B cell malignancies. Journal of hematotherapy. ,vol. 4, pp. 433- 437 ,(1995) , 10.1089/SCD.1.1995.4.433