Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal−Organic Frameworks

作者: Denise Cunha , Mouna Ben Yahia , Shaun Hall , Stuart R Miller , Hubert Chevreau

DOI: 10.1021/CM400798P

关键词: NanotechnologyActive ingredientDehydrationDistilled waterSolventChemical engineeringMoleculeImmersion (virtual reality)KineticsMaterials sciencePorosity

摘要: A joint experimental and computational systematic exploration of the driving forces that govern (i) encapsulation of active ingredients (solvent, starting material dehydration, drug/material ratio, immersion time, and several consecutive impregnations) and (i) its kinetics of delivery (structure, polarity,...) was performed using a series of porous biocompatible metal–organic frameworks (MOFs) that bear different topologies, connectivities, and chemical compositions. The liporeductor cosmetic caffeine was selected …

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