Method and composition for selectively inhibiting melanoma
作者： Tapas K. DasGupta , John M. Pezzuto , Darrick S. H. L. Kim
DOI:
关键词: Betulinic acid 、 Composition (visual arts) 、 Tumor growth 、 Derivative (chemistry) 、 Active compound 、 Stereochemistry 、 Melanoma 、 Chemistry
摘要: A composition and method of preventing or inhibiting tumor growth, treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid a betulinic derivative is the active compound composition, which topically applied to situs tumor.
google.com.tr 参考文章(20)
Achla Behl Khanna, Sunder Ramadoss, Mannu Jaggi, Mohammad Jamshed Ahmed Siddiqui, Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors ,(1999)
A.K. Batta, S. Rangaswami, Angiospermae dicotyledonae: crystalline chemical components of some vegetable drugs Phytochemistry. ,vol. 12, ,(1973) , 10.1016/S0031-9422(00)84654-3
Salvador Máñez, M.Carmen Recio, Rosa M Giner, José-Luis Rı́os, Effect of selected triterpenoids on chronic dermal inflammation. European Journal of Pharmacology. ,vol. 334, pp. 103- 105 ,(1997) , 10.1016/S0014-2999(97)01187-4
Yoshiki Kashiwada, Fumio Hashimoto, L. Mark Cosentino, Chin-Ho Chen, Patricia E. Garrett, Kuo-Hsiung Lee, Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents Journal of Medicinal Chemistry. ,vol. 39, pp. 1016- 1017 ,(1996) , 10.1021/JM950922Q
K. Yasukawa, SY. Yu, S. Yamanouchi, M. Takido, T. Akihisa, T. Tamura, Some lupane-type triterpenes inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine. ,vol. 1, pp. 309- 313 ,(1995) , 10.1016/S0944-7113(11)80008-5
K. Yasukawa, M. Takido, T. Matsumoto, M. Takeuchi, S. Nakagawa, Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis. Oncology. ,vol. 48, pp. 72- 76 ,(1991) , 10.1159/000226898
Emily Pisha, Heebyung Chai, Ik-Soo Lee, Tangai E. Chagwedera, Norman R. Farnsworth, Geoffrey A. Cordell, Christopher W.W. Beecher, Harry H.S. Fong, A. Douglas Kinghorn, Daniel M. Brown, Mansukh C. Wani, Monroe E. Wall, Tina J. Hieken, Tapas K. Das Gupta, John M. Pezzuto, Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis Nature Medicine. ,vol. 1, pp. 1046- 1051 ,(1995) , 10.1038/NM1095-1046
Toshihiro Fujioka, Yoshiki Kashiwada, Robert E. Kilkuskie, L. Mark Cosentino, Lawrence M. Ballas, Jack B. Jiang, William P. Janzen, Ih-Sheng Chen, Kuo-Hsiung Lee, Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. Journal of Natural Products. ,vol. 57, pp. 243- 247 ,(1994) , 10.1021/NP50104A008
Shi Yong Ryu, Sang Un Choi, Seung Ho Lee, Chong Ock Lee, Zaesung No, Jong Woong Ahn, Antitumor triterpenes from medicinal plants Archives of Pharmacal Research. ,vol. 17, pp. 375- 377 ,(1994) , 10.1007/BF02974180
Takao Konoshima, Midori Takasaki, Mutsuo Kozuka, Harukuni Tokuda, Studies on inhibitors of skin-tumor promotion, I. Inhibitory effects of triterpenes from Euptelea polyandra on Epstein-Barr virus activation. Journal of Natural Products. ,vol. 50, pp. 1167- 1170 ,(1987) , 10.1021/NP50054A031