MicroRNA, DNA Repair, and Cancer

摘要: Genomic instability is a hallmark of cancer cells and one the underlying mechanisms probably caused by failure to repair DNA damages that have been passed on progeny cells. Cells evolved many types counteract induced exogenous insults, such as ionizing radiation, ultraviolet chemical reagents, or endogenous stimuli-like reactive oxygen species (ROS). These constitute an elaborate genome maintenance system protect genomic integrity therefore defend tumorigenesis. Most recently, microRNAs (miRNAs) reported be new class regulators modulate damage response pathways targeting protein components machinery. Here, we summarize highlight miRNAs shown regulate different discuss their roles in carcinogenesis implications therapy.