Synthesis of serotonin by pineal glands of the rat in organ culture.
作者： HARVEY M. SHEIN , RICHARD J. WURTMAN , JULIUS AXELROD
DOI: 10.1038/213730A0
关键词: Tryptophan 、 Indole test 、 Endocrinology 、 5-Hydroxytryptophan 、 Serotonin 、 Melatonin 、 Organ culture 、 Internal medicine 、 Chemistry 、 Pineal gland 、 Hormone
摘要: THE pineal gland of the rat has been shown to contain large quantities indole serotonin1. This organ can also metabolize serotonin by a unique pathway form hormone melatonin (5-methoxy N-acetyltryptamine)2. The content serotonin1,3 and activity melatonin-forming enzyme4 in have found vary with 24 h cycle. These rhythms are controlled information transmitted through its sympathetic nerves3,5.
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