Cytotoxic 3,4-seco-Cycloartane Triterpenes from Gardenia sootepensis
作者： Thanesuan Nuanyai , Reungrit Sappapan , Thapong Teerawatananond , Nongnuj Muangsin , Khanitha Pudhom
DOI: 10.1021/NP900156K
关键词: Biochemistry 、 Biological activity 、 Gardenia 、 Pharmacognosy 、 Lactone 、 Cytotoxicity 、 Triterpene 、 Chemistry 、 Stereochemistry 、 Terpenoid 、 Terpene
摘要: Five new 3,4-seco-cycloartanes, sootepins A−E (1−5), along with four known triterpenes (6−9), were isolated from the apical buds of Gardenia sootepensis. Their structures elucidated on basis spectroscopic methods (1D and 2D NMR, HRESIMS, X-ray crystallography), compounds tested for in vitro cytotoxic activity against human breast (BT474), lung (CHAGO), liver (Hep-G2), gastric (KATO-3), colon (SW-620) cancer cell lines. Generally, possessing an exomethylene γ-lactone ring showed broad cytotoxicity all lines tested.
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