2012-2013 Seasonal Influenza Vaccine Effectiveness against Influenza Hospitalizations: Results from the Global Influenza Hospital Surveillance Network

摘要: Background The effectiveness of currently licensed vaccines against influenza has not been clearly established, especially among individuals at increased risk for complications from influenza. We used a test-negative approach to estimate vaccine (IVE) hospitalization with laboratory-confirmed based on data collected the Global Influenza Hospital Surveillance Network (GIHSN). Methods and Findings This was multi-center, prospective, active surveillance, hospital-based epidemiological study during 2012–2013 season. Data were hospitals participating in GIHSN, including five Spain, France, four Russian Federation. confirmed by reverse transcription-polymerase chain reaction. IVE estimated adult patients targeted vaccination who swabbed within 7 days symptom onset. The overall adjusted 33% (95% confidence interval [CI], 11% 49%). Point estimates 23% CI, −26% 53%) A(H1N1)pdm09, 30% −37% 64%) A(H3N2), 43% 17% 60%) B/Yamagata. similar subjects <65 ≥65 years age (35% [95% −15% 63%] vs.31% 4% 51%]). Heterogeneity site-specific high (I2 = 63.4%) A(H1N1)pdm09 age. B/Yamagata homogenous 0.0%). Conclusions These results, which GIHSN season, showed that provided low moderate protection hospital admission adults vaccination. In this population, sensitive group site. moderately effective preventing admissions all sites groups.