The Effect of a Single Bout of Continuous Aerobic Exercise on Glucose, Insulin and Glucagon Concentrations Compared to Resting Conditions in Healthy Adults: A Systematic Review, Meta-Analysis and Meta-Regression

摘要: Elevated glucose and insulin levels are major risk factors in the development of cardiometabolic disease. Aerobic exercise is widely recommended to improve glycaemic control, yet its acute effect on glycaemia glucoregulatory hormones has not been systematically reviewed analysed healthy adults. To determine a single bout continuous aerobic circulating glucose, insulin, glucagon concentrations CENTRAL, CINAHL, Embase, Global Health, HMIC, Medline, PubMed, PsycINFO, ScienceDirect, Scopus Web Science databases were searched from inception May 2020. Papers included if they reported randomised, crossover study measuring and/or before immediately after (≥ 30 min) compared time-matched, resting control arm The bias quality evidence assessed using Cochrane Risk Bias Tool GRADE approach, respectively. Random-effects meta-analyses performed for glucagon. Sub-group meta-regression categorical (metabolic state [postprandial or fasted], mode [cycle ergometer treadmill]) (age, body mass index, % males, maximal capacity, duration, intensity) covariates, 42 papers (51 studies) considered eligible: (45 studies, 391 participants), (38 377 participants) (5 47 participants). Acute had no significant (mean difference: − 0.05 mmol/L; 95% CI, 0.22 0.13 mmol/L; P = 0.589; I2: 91.08%, large heterogeneity; moderate-quality evidence). significantly decreased 18.07 pmol/L; 30.47 5.66 pmol/L; P = 0.004; 95.39%, evidence) increased 24.60 ng/L; 16.25 32.95 ng/L; P < 0.001; 79.36%, identified that metabolic modified responses, which 0.27 mmol/L; 0.55 0.00 mmol/L; P = 0.049; 89.72%, heterogeneity) 42.63 pmol/L; 66.18 19.09 pmol/L; 81.29%, postprandial but fasted state. Meta-regression revealed also moderated by duration capacity. decreases increases irrespective Therefore, undertaken an effective strategy adults, supporting role reducing disease incidence. CRD42020191345.