Randomized Trial of Black Cohosh for the Treatment of Hot Flashes Among Women With a History of Breast Cancer
作者： Judith S. Jacobson , Andrea B. Troxel , Joel Evans , Lorissa Klaus , Linda Vahdat
DOI: 10.1200/JCO.2001.19.10.2739
关键词: Tamoxifen 、 Randomized controlled trial 、 Menopause 、 Hot flash 、 Medicine 、 Breast cancer 、 Black cohosh 、 Menopausal Symptom 、 Placebo 、 Internal medicine 、 Gynecology
摘要: PURPOSE: Most breast cancer survivors experience hot flashes; many use complementary or alternative remedies for these symptoms. We undertook a randomized clinical trial of black cohosh, widely used herbal remedy menopausal symptoms, among patients. PATIENTS AND METHODS: Patients diagnosed with who had completed their primary treatment were randomly assigned to cohosh placebo, stratified on tamoxifen use. At enrollment, patients questionnaire about demographic factors and Before starting take the pills at 30 60 days, they 4-day flash diary. final visit, another symptom questionnaire. Follicle-stimulating hormone (FSH) luteinizing (LH) levels measured in subset first visits. RESULTS: Of 85 (59 tamoxifen, 26 not tamoxifen) enrolled study, 42 43 placebo; 69 c...
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