A hot spot of binding energy in a hormone-receptor interface
作者： T. Clackson , J. Wells
关键词: Binding site 、 Receptor 、 Tryptophan 、 Alanine 、 Biophysics 、 Stereochemistry 、 Binding energy 、 Side chain 、 Chemistry 、 Globular protein 、 Hydrogen bond
摘要: … Substitution by alanine deletes all interactions made by atoms beyond the P carbon and should reveal the contribution to binding energy made by the removed portion of the side chain (…
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Robert E. Hawkins, Stephen J. Russell, Michael Baier, Greg Winter, The Contribution of Contact and Non-contact Residues of Antibody in the Affinity of Binding to Antigen: The Interaction of Mutant D1.3 Antibodies with Lysozyme Journal of Molecular Biology. ,vol. 234, pp. 958- 964 ,(1993) , 10.1006/JMBI.1993.1650
J Janin, C Chothia, The structure of protein-protein recognition sites. Journal of Biological Chemistry. ,vol. 265, pp. 16027- 16030 ,(1990) , 10.1016/S0021-9258(17)46181-3
G Fuh, M G Mulkerrin, S Bass, N McFarland, M Brochier, J H Bourell, D R Light, J A Wells, The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain. Journal of Biological Chemistry. ,vol. 265, pp. 3111- 3115 ,(1990) , 10.1016/S0021-9258(19)39741-8
S A Spencer, R G Hammonds, W J Henzel, H Rodriguez, M J Waters, W I Wood, Rabbit liver growth hormone receptor and serum binding protein. Purification, characterization, and sequence. Journal of Biological Chemistry. ,vol. 263, pp. 7862- 7867 ,(1988) , 10.1016/S0021-9258(18)68577-1
James A. Wells, Systematic mutational analyses of protein-protein interfaces. Methods in Enzymology. ,vol. 202, pp. 390- 411 ,(1991) , 10.1016/0076-6879(91)02020-A
Robin Weiss, Viruses associated with human leukaemia Nature. ,vol. 254, pp. 101- 102 ,(1975) , 10.1038/254101A0
B. C. Cunningham, J. A. Wells, Rational design of receptor-specific variants of human growth hormone. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 3407- 3411 ,(1991) , 10.1073/PNAS.88.8.3407
Robert F. Kelley, Mark P. O'Connell, Thermodynamic analysis of an antibody functional epitope Biochemistry. ,vol. 32, pp. 6828- 6835 ,(1993) , 10.1021/BI00078A005
Z. Otwinowski, R. W. Schevitz, R.-G. Zhang, C. L. Lawson, A. Joachimiak, R. Q. Marmorstein, B. F. Luisi, P. B. Sigler, Crystal structure of trp repressor/operator complex at atomic resolution. Nature. ,vol. 335, pp. 321- 329 ,(1988) , 10.1038/335321A0
William Somers, Mark Ultsch, Abraham M. De Vos, Anthony A. Kossiakoff, The X-ray structure of a growth hormone–prolactin receptor complex Nature. ,vol. 372, pp. 478- 481 ,(1994) , 10.1038/372478A0