Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with primary progressive multiple sclerosis.
作者： M Filippi , A Campi , V Martinelli , B Colombo , T Yousry
关键词: In vivo 、 In patient 、 Nuclear medicine 、 Medicine 、 Text mining 、 Magnetic resonance imaging 、 Primary Progressive Multiple Sclerosis 、 Pentetic acid 、 Multiple sclerosis 、 Central nervous system disease
摘要: This study was performed to evaluate whether a triple dose of gadolinium-DTPA (Gd-DTPA) increases the sensitivity brain MRI for detecting enhancing lesions in patients with primary progressive multiple sclerosis (PPMS). T1 weighted obtained 10 PPMS two sessions. In first session, one scan five seven minutes after injection 0.1 mmol/kg Gd-DTPA (standard dose). second six 24 hours later, before and scans hour 0.3 (triple dose) were obtained. Four detected when standard used. The numbers increased 13 such used 14 delayed scans. mean contrast ratio higher than those present both (P < 0.0009) = 0.04). These data indicate that many more can be PPMS. is important planning clinical trials presence inflammation vivo patients.
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sci-hub.se 参考文章(29)
William R. Kinkel, Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease): Computed Tomographic, Nuclear Magnetic Resonance, and Clinical Correlations JAMA Neurology. ,vol. 42, pp. 951- 959 ,(1985) , 10.1001/ARCHNEUR.1985.04060090033010
C. P. HAWKINS, P. M. G. MUNRO, F. MACKENZIE, J. KESSELRING, P. S. TOFTS, E. P. G. H. DU BOULAY, D. N. LANDON, W. I. McDONALD, Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers. Brain. ,vol. 113, pp. 365- 378 ,(1990) , 10.1093/BRAIN/113.2.365
WILLIAM T.C. YUH, DAVID J. FISHER, NINA A. MAYR-YUH, E. TURGUT TALI, HOANG D. NGUYEN, FENG GAO, JAMES C. EHRHARDT, Review of the use of high-dose gadoteridol in the magnetic resonance evaluation of central nervous system tumors. Investigative Radiology. ,vol. 27, ,(1992) , 10.1097/00004424-199208001-00008
C. P. HAWKINS, F. MACKENZIE, P. TOFTS, E. P. G. H. DU BOULAY, W. I. MCDONALD, PATTERNS OF BLOOD-BRAIN BARRIER BREAKDOWN IN INFLAMMATORY DEMYELINATION Brain. ,vol. 114, pp. 801- 810 ,(1991) , 10.1093/BRAIN/114.2.801
D H Miller, F Barkhof, I Berry, L Kappos, G Scotti, A J Thompson, Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 54, pp. 683- 688 ,(1991) , 10.1136/JNNP.54.8.683
T. Revesz, D. Kidd, A. J. Thompson, R. O. Barnard, W. I. McDonald, A comparison of the pathology of primary and secondary progressive multiple sclerosis Brain. ,vol. 117, pp. 759- 765 ,(1994) , 10.1093/BRAIN/117.4.759
E. S. Sears, A. McCammon, R. Bigelow, L. A. Hayman, Maximizing the harvest of contrast enhancing lesions in multiple sclerosis Neurology. ,vol. 32, pp. 815- 815 ,(1982) , 10.1212/WNL.32.8.815
Val M. Runge, John E. Kirsch, Vickie J. Burke, Ann C. Price, Kevin L. Nelson, Greg S. Thomas, Bruce L. Dean, Charles Lee, High-dose gadoteridol in MR imaging of intracranial neoplasms Journal of Magnetic Resonance Imaging. ,vol. 2, pp. 9- 18 ,(1992) , 10.1002/JMRI.1880020103
D. H. Miller, I. E. C. Ormerod, A. Gibson, E. P. G. H. du Boulay, P. Rudge, W. I. McDonald, MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis Neuroradiology. ,vol. 29, pp. 226- 231 ,(1987) , 10.1007/BF00451758
David Katz, Jeffery K. Taubenberger, Barbara Cannella, Dale E. McFarlin, Cedric S. Raine, Henry F. McFarland, Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis Annals of Neurology. ,vol. 34, pp. 661- 669 ,(1993) , 10.1002/ANA.410340507