Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes.

摘要: Measurement of ultrasound backscattering is a promising diagnostic technique for arthroscopic evaluation articular cartilage. However, contribution collagen and chondrocytes on speed sound in cartilage not fully understood experimentally difficult to study. Agarose hydrogels have been used tissue engineering applications Therefore, the aim this study was simulate propagation high frequency (40 MHz) agarose scaffolds with varying concentrations (1 32 × 10(6) cells/ml) (1.56-200 mg/ml) using transversely isotropic two-dimensional finite difference time domain method (FDTD). Backscatter were evaluated from simulated pulse-echo through transmission measurements, respectively. Ultrasound backscatter increased increasing chondrocyte concentrations. Furthermore, concentration. observed The present suggests that FDTD may some applicability simulations scattering constructs containing chondrocytes. Findings indicate significant role as scatterers can aid development modeling approaches understanding how architecture affects ultrasound.