Pain from the Arthritic Joint
作者： Hans-Georg Schaible , Andrea Ebersberger
DOI: 10.1007/978-1-4419-0226-9_12
关键词: Stimulation 、 Prostaglandin E2 、 Anesthesia 、 Neurokinin A 、 Spinal cord 、 Calcitonin gene-related peptide 、 Neuroscience 、 Medicine 、 Diffuse noxious inhibitory control 、 Substance P 、 Nociception
摘要: Nociceptive input from the joint is processed in spinal cord neurons which are either only activated by mechanical stimulation of and other deep tissue, e.g. adjacent muscles, or receive convergent inputs joint, muscles skin. Neurons with show pronounced hyperexcitability during development inflammation (enhanced responses to inflamed as well healthy structures, reduction threshold high expansion receptive field). This state maintained persistent inflammation. The under strong control descending inhibition increases at least acute phase Both induction inflammation-induced its maintenance dependent on glutamate, substance P, neurokinin A, CGRP. Spinal prostaglandin E2 supports hyperexcitability. By contrast, D2 rather attenuates established
springer.com
sci-hub.st 参考文章(76)
H. G. Schaible, R. F. Schmidt, Time course of mechanosensitivity changes in articular afferents during a developing experimental arthritis. Journal of Neurophysiology. ,vol. 60, pp. 2180- 2195 ,(1988) , 10.1152/JN.1988.60.6.2180
X. He, U. Proske, H. G. Schaible, R. F. Schmidt, Acute inflammation of the knee joint in the cat alters responses of flexor motoneurons to leg movements Journal of Neurophysiology. ,vol. 59, pp. 326- 340 ,(1988) , 10.1152/JN.1988.59.2.326
Daniel Le Bars, Luis Villanueva, Chapter 20 Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways Progress in Brain Research. ,vol. 77, pp. 275- 299 ,(1988) , 10.1016/S0079-6123(08)62795-8
Volker Neugebauer, Thomas Lücke, Blair Grubb, Hans-Georg Schaible, The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle Neuroscience Letters. ,vol. 170, pp. 237- 240 ,(1994) , 10.1016/0304-3940(94)90327-1
Enrique Vasquez, Karl-Jürgen Bär, Andrea Ebersberger, Barbara Klein, Horacio Vanegas, Hans-Georg Schaible, Spinal Prostaglandins Are Involved in the Development But Not the Maintenance of Inflammation-Induced Spinal Hyperexcitability The Journal of Neuroscience. ,vol. 21, pp. 9001- 9008 ,(2001) , 10.1523/JNEUROSCI.21-22-09001.2001
H. -G. Schaible, Peripheral and central mechanisms of pain generation Handbook of experimental pharmacology. ,vol. 177, pp. 3- 28 ,(2006) , 10.1007/978-3-540-33823-9_1
Martin Koltzenburg, Stephen B. McMahon, Wall and Melzack's Textbook of Pain ,(2005)
Lars Arendt-Nielsen, RenéJ. Laursen, Asbjørn M. Drewes, Referred pain as an indicator for neural plasticity. Progress in Brain Research. ,vol. 129, pp. 343- 356 ,(2000) , 10.1016/S0079-6123(00)29026-2
Nicolas Danziger, Jeanne Weil-Fugazza, Daniel Le Bars, Didier Bouhassira, Stage-dependent changes in the modulation of spinal nociceptive neuronal activity during the course of inflammation. European Journal of Neuroscience. ,vol. 13, pp. 230- 240 ,(2001) , 10.1046/J.0953-816X.2000.01375.X
CJ Woolf, PD Wall, Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat The Journal of Neuroscience. ,vol. 6, pp. 1433- 1442 ,(1986) , 10.1523/JNEUROSCI.06-05-01433.1986