Non-invasive papillary urothelial neoplasms: The 2004 WHO/ISUP classification system

摘要: The classification and grading of papillary urothelial neoplasms has been a long-standing subject controversy. Previously, numerous diverse schemes for bladder tumor, including the 1973 World Health Organization (WHO) classification, existed whereby one major limitations was poor inter-observer reproducibility among pathologists. WHO/International Society Urological Pathology (ISUP) consensus system urinary developed in 1998 revised most recently 2003 (published 2004). Importantly, current provides detailed histological criteria lesions allows designation lesion (papillary neoplasm low malignant potential) with negligible risk progression. Thus, latest is designed to be universally acceptable tumors that not only could effectively used by pathologists, urologists, oncologists, but also stratifies into prognostically significant categories. This article outlines 2004 WHO/ISUP regarding specific non-invasive clinical significance each category.