t(3;21)(q26;q22): A Recurring Chromosomal Abnormality in Therapy-Related Myelodysplastic Syndrome and Acute Myeloid Leukemia
作者： CM Rubin , RA Larson , J Anastasi , JN Winter , M Thangavelu
DOI: 10.1182/BLOOD.V76.12.2594.2594
关键词: Premalignant lesion 、 Chromosomal Abnormality 、 Chromosomal translocation 、 Monosomy 、 Long arm 、 Therapy-related myelodysplastic syndrome 、 Pathology 、 Myeloid leukemia 、 Biology
摘要: ALIGNANT CELLS of more than 95% patients M with therapy-related myelodysplastic syndrome (tMDS) and acute myeloid leukemia (t-AML) are characterized by acquired clonal chromosomal abnormalities.’ Complete loss chromosomes 5 and/or 7 or partial monosomy the long arm these is found in 90% abnormal cases; results from interstitial deletions unbalanced translocations. Two recurring translocations have been described that result material one both
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bloodjournal.org参考文章(25)
MJ Ratain, LS Kaminer, JD Bitran, RA Larson, MM Le Beau, C Skosey, S Purl, PC Hoffman, J Wade, JW Vardiman, Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood. ,vol. 70, pp. 1412- 1417 ,(1987) , 10.1182/BLOOD.V70.5.1412.BLOODJOURNAL7051412
F. H. Ruddle, M. Rabin, L. C. Kühn, A. McClelland, Regional localization of the human transferrin receptor gene to 3q26.2----qter American Journal of Human Genetics. ,vol. 37, pp. 1112- 1116 ,(1985)
M M Le Beau, K S Albain, R A Larson, J W Vardiman, E M Davis, R R Blough, H M Golomb, J D Rowley, Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. Journal of Clinical Oncology. ,vol. 4, pp. 325- 345 ,(1986) , 10.1200/JCO.1986.4.3.325
D. K. Watson, M. J. McWilliams-Smith, M. F. Nunn, P. H. Duesberg, S. J. O'Brien, T. S. Papas, The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 7294- 7298 ,(1985) , 10.1073/PNAS.82.21.7294
H. R. Gralnick, H. R. Gralnick, C. Sultan, J. M. Bennett, M. T. Daniel, D. Catovsky, G. Flandrin, D. A. G. Galton, Proposals for the classification of the myelodysplastic syndromes. British Journal of Haematology. ,vol. 51, pp. 189- 199 ,(1982) , 10.1111/J.1365-2141.1982.TB02771.X
K.E. Mogensen, F. Vignaux, I. Gresser, Enhanced expression of cellular receptors for human interferon α on peripheral lymphocytes from patients with down's syndrome FEBS Letters. ,vol. 140, pp. 285- 287 ,(1982) , 10.1016/0014-5793(82)80915-0
V. Rao, T. Papas, E. Reddy, erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation Science. ,vol. 237, pp. 635- 639 ,(1987) , 10.1126/SCIENCE.3299708
Hagop M. Kantarjian, Michael J. Keating, Ronald S. Walters, Miloslav Beran, Peter McLaughlin, Kenneth B. McCredie, And Emil J Freireich, The association of specific "favorable" cytogenetic abnormalities with secondary leukemia. Cancer. ,vol. 58, pp. 924- 927 ,(1986) , 10.1002/1097-0142(19860815)58:4<924::AID-CNCR2820580420>3.0.CO;2-Y
Ching-Hon Pui, Frederick G. Behm, Susana C. Raimondi, Richard K. Dodge, Stephen L. George, Gaston K. Rivera, Joseph Mirro, David K. Kalwinsky, Gary V. Dahl, Sharon B. Murphy, William M. Crist, Dorothy L. Williams, Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. The New England Journal of Medicine. ,vol. 321, pp. 136- 142 ,(1989) , 10.1056/NEJM198907203210302
Jacques M.J.C. Scheres, Theo W.J. Hustinx, Joep P.M. Geraedts, C.Henk W. Leeksma, Paul S. Meltzer, Translocation 1; 7 in hematologic disorders: a brief review of 22 cases Cancer Genetics and Cytogenetics. ,vol. 18, pp. 207- 213 ,(1985) , 10.1016/0165-4608(85)90085-8