Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

摘要: Control of the stem-like tumour cell population is considered key to realizing long-term survival patients with glioblastoma, one most devastating human malignancies. To date, possible therapeutic targets and targeting methods have been described, but none has yet proven target glioblastoma cells in brain extent necessary provide a benefit. Here we show that JNK vivo, activity which required for maintenance cells, via transient, systemic administration small-molecule inhibitor depletes self-renewing tumour-initiating populations within established tumours, inhibits formation by brain, substantial benefit without evidence adverse events. Our findings not only implicate also demonstrate viable, clinically relevant control cells.