Bacterial cellulose-collagen nanocomposite for bone tissue engineering

作者: Sybele Saska , Lucas Novaes Teixeira , Paulo Tambasco de Oliveira , Ana Maria Minarelli Gaspar , Sidney José Lima Ribeiro

DOI: 10.1039/C2JM33762B

关键词: Bone regenerationCell morphologyBiomaterialBacterial celluloseViability assayMembraneType I collagenCell cultureBiophysicsMaterials science

摘要: A nanocomposite based on bacterial cellulose (BC) and type I collagen (COL) was evaluated for in vitro bone regeneration. BC membranes were modified by glycine esterification followed by cross-linking of type I collagen employing 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide. Collagen incorporation was studied by spectroscopy analysis. X-Ray diffraction showed changes in the BC crystallinity after collagen incorporation. The elastic modulus and tensile strength for BC-COL decreased, while the …

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