Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model
作者： Yun Peng , Junjun Xi , Yue Sun , Guijie Chen , Daxiang Li
DOI: 10.1111/IJFS.14466
关键词: Fluoride 、 Caco-2 、 Paracellular transport 、 Biophysics 、 Aluminium 、 Epigallocatechin gallate 、 Aluminium fluoride 、 Bioavailability 、 Cell culture 、 Chemistry
摘要: Previous work showed that the bioavailability of fluoride in dark tea was lower than NaF solution. However, limited information is available indicating effects components on bioavailability. In this study, were evaluated Caco‐2 cell line model. Additionally, mechanism effect aluminium transport investigated. The result 10–100 μm epigallocatechin gallate (EGCG) could not influence transport. Al³⁺ significantly decreased both apical‐basolateral and basolateral‐apical directions. Moreover, form different forms complexes, which transported through cells by pathways. F⁻ mainly dependent paracellular pathway active involving Cl⁻ channels. played a predominant role AlF₃. participated AlF₂⁺
sci-hub.se 参考文章(34)
Marshall H. Montrose, Juha Kere, Chapter 8 Anion absorption in the intestine: Anion transporters, short-chain fatty acids, and role of the DRA gene product Current Topics in Membranes. ,vol. 50, pp. 301- 328 ,(2000) , 10.1016/S1063-5823(00)50010-6
Mahboobeh Ghoochani, Sakine Shekoohiyan, Masoud Yunesian, Shahrokh Nazmara, Amir Hossein Mahvi, None, Determination of aluminum and zinc in infusion tea cultivated in north of Iran Journal of Environmental Health Science and Engineering. ,vol. 13, pp. 49- 49 ,(2015) , 10.1186/S40201-015-0196-9
Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt, Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability Gastroenterology. ,vol. 96, pp. 736- 749 ,(1989) , 10.1016/S0016-5085(89)80072-1
Mizuki Shigeshiro, Soichi Tanabe, Takuya Suzuki, Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis Journal of Functional Foods. ,vol. 5, pp. 949- 955 ,(2013) , 10.1016/J.JFF.2013.02.008
Xiaobai Liu, Zhenhua Wang, Ping Wang, Bo Yu, Yunhui Liu, Yixue Xue, Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling. BMC Complementary and Alternative Medicine. ,vol. 13, pp. 187- 187 ,(2013) , 10.1186/1472-6882-13-187
Gerard Leblondel, Yves Mauras, Annie Cailleux, Pierre Allain, Transport measurements across Caco-2 monolayers of different organic and inorganic selenium: influence of sulfur compounds. Biological Trace Element Research. ,vol. 83, pp. 191- 206 ,(2001) , 10.1385/BTER:83:3:191
Ya Lun Su, Lai Kwok Leung, Yu Huang, Zhen-Yu Chen, Stability of tea theaflavins and catechins Food Chemistry. ,vol. 83, pp. 189- 195 ,(2003) , 10.1016/S0308-8146(03)00062-1
Cem Ekmekcioglu, A physiological approach for preparing and conducting intestinal bioavailability studies using experimental systems Food Chemistry. ,vol. 76, pp. 225- 230 ,(2002) , 10.1016/S0308-8146(01)00291-6
Manfred Kansy, Per Artursson, Alex Avdeef, Stefanie Bendels, Li Di, Gerhard F. Ecker, Bernard Faller, Holger Fischer, Grégori Gerebtzoff, Hans Lennernaes, Frank Senner, Kiyohiko Sugano, Coexistence of passive and carrier-mediated processes in drug transport Nature Reviews Drug Discovery. ,vol. 9, pp. 597- 614 ,(2010) , 10.1038/NRD3187
Ina Hubatsch, Eva G E Ragnarsson, Per Artursson, Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers Nature Protocols. ,vol. 2, pp. 2111- 2119 ,(2007) , 10.1038/NPROT.2007.303