Dinucleoside polyphosphates in the eye: from physiology to therapeutics

摘要: Abstract Diadenosine polyphosphates are a family of dinucleotides with emerging biochemical, physiological, pharmacological and therapeutic properties in the eye other tissues. These compounds formed by two adenosine moieties linked their ribose 5′-ends to variable number phosphates. present as active components ocular secretions such tears aqueous humour they can activate P2 purinergic receptors on surface, anterior segment retina. Both metabotropic ionotropic actions mediated P2Y P2X receptors, respectively responsible for control processes induction tear secretion, lysozyme production or acceleration corneal wound healing. Inside dinucleotide Ap 4 A reduce intraocular pressure acting 1 trabecular meshwork cells 2 cholinergic terminals located ciliary muscle. In retina, derivatives diadenosine improve re-absorption fluids retinal detachment. Altogether, not only roles physiology but it is also possible that may serve help treatment some pathologies.