Orphan G-protein-coupled receptors and natural ligand discovery

作者: Andrew D Howard , George McAllister , Scott D Feighner , Qingyun Liu , Ravi P Nargund

DOI: 10.1016/S0165-6147(00)01636-9

关键词: Function (biology)BiologySignal transductionTransmembrane proteinBiochemistryReceptorG protein-coupled receptorRhodopsinRhodopsin-like receptorsHeterotrimeric G proteinCell biologyToxicologyPharmacology

摘要: … (3) Extracts of tissues can be tested using functional assays to guide ligand fractionation, purification and molecular characterization. Ligands discovered by this method include …

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