Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

摘要: We have used a panel of Chinese hamster X human somatic cell hybrids, each containing various portions chromosome 21 as the only detectable component, for regional mapping cloned, 21-derived DNA sequences. Thirty unique and very low-repeat sequences were mapped to short arm three sections long arm. Three map proximal part terminal band 21q22.3, five distal this band. Some these may represent parts gene that be relevant pathogenesis Down syndrome, 21q22 is area required present in triplicate full clinical picture.