作者: Nadine Provencal , Renaud Massart , Zsofia Nemoda , Stephen Suomi
DOI: 10.1007/978-3-319-24493-8_7
关键词: DNA methylation 、 Social environment 、 Paternal care 、 Health problems 、 Organism 、 Phenotype 、 Causality 、 Genetics 、 Biology 、 Neuroscience 、 Epigenetics
摘要: Early life is one of the most important and sensitive periods during development an individual. During this stage, body especially brain are known to be greatly responsive environmental cues, such as early social environment. As a consequence, adverse experiences in humans associated with wide range health problems adulthood. The broad phenotypes stress (ELS) suggests system-wide response organism, which yet determined. In last decade, increasing evidence that epigenetic mechanisms underlie effects ELS on adult human health. However, there critical challenges delineating direct profiles studies. It impossible randomize rare studies where complete information about past insults available, would allow us conclude causality. Nonhuman primates offer several advantages addressing these challenges. This chapter focuses parental deprivation models rhesus macaques have been shown produce array behavioral, physiological, neurobiological deficits parallel those identified subjected ELS. describes for alterations induced by differential rearing model points out differences between tissue-specific versus multi-tissue changes outlines possible occur. addition, it highlights need multi-omics longitudinal better understand trajectories exposure their impact