Alterations in DNA Methylation and Hydroxymethylation Due to Parental Care in Rhesus Macaques

作者: Nadine Provencal , Renaud Massart , Zsofia Nemoda , Stephen Suomi

DOI: 10.1007/978-3-319-24493-8_7

关键词: DNA methylationSocial environmentPaternal careHealth problemsOrganismPhenotypeCausalityGeneticsBiologyNeuroscienceEpigenetics

摘要: Early life is one of the most important and sensitive periods during development an individual. During this stage, body especially brain are known to be greatly responsive environmental cues, such as early social environment. As a consequence, adverse experiences in humans associated with wide range health problems adulthood. The broad phenotypes stress (ELS) suggests system-wide response organism, which yet determined. In last decade, increasing evidence that epigenetic mechanisms underlie effects ELS on adult human health. However, there critical challenges delineating direct profiles studies. It impossible randomize rare studies where complete information about past insults available, would allow us conclude causality. Nonhuman primates offer several advantages addressing these challenges. This chapter focuses parental deprivation models rhesus macaques have been shown produce array behavioral, physiological, neurobiological deficits parallel those identified subjected ELS. describes for alterations induced by differential rearing model points out differences between tissue-specific versus multi-tissue changes outlines possible occur. addition, it highlights need multi-omics longitudinal better understand trajectories exposure their impact

参考文章(146)
Robert A. Waterland, Randy L. Jirtle, Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology. ,vol. 23, pp. 5293- 5300 ,(2003) , 10.1128/MCB.23.15.5293-5300.2003
X. Li, W. Wei, Q.-Y. Zhao, J. Widagdo, D. Baker-Andresen, C. R. Flavell, A. D'Alessio, Y. Zhang, T. W. Bredy, Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 7120- 7125 ,(2014) , 10.1073/PNAS.1318906111
Sue Howell, Greg Westergaard, Beth Hoos, Tara J. Chavanne, Susan E. Shoaf, Allison Cleveland, Philip J. Snoy, Stephen J. Suomi, J. Dee Higley, Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques American Journal of Primatology. ,vol. 69, pp. 851- 865 ,(2007) , 10.1002/AJP.20369
Timothy K. Newman, Yana V. Syagailo, Christina S. Barr, Jens R. Wendland, Maribeth Champoux, Markus Graessle, Stephen J. Suomi, J. Dee Higley, Klaus-Peter Lesch, Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys Biological Psychiatry. ,vol. 57, pp. 167- 172 ,(2005) , 10.1016/J.BIOPSYCH.2004.10.012
Guillermo Barreto, Andrea Schäfer, Joachim Marhold, Dirk Stach, Suresh K. Swaminathan, Vikas Handa, Gabi Döderlein, Nicole Maltry, Wei Wu, Frank Lyko, Christof Niehrs, Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation Nature. ,vol. 445, pp. 671- 675 ,(2007) , 10.1038/NATURE05515
M Champoux, A Bennett, C Shannon, J D Higley, K P Lesch, S J Suomi, Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Molecular Psychiatry. ,vol. 7, pp. 1058- 1063 ,(2002) , 10.1038/SJ.MP.4001157
Dana C. Dolinoy, Jennifer R. Weidman, Robert A. Waterland, Randy L. Jirtle, Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome Environmental Health Perspectives. ,vol. 114, pp. 567- 572 ,(2006) , 10.1289/EHP.8700
K.-P. Lesch, D. Bengel, A. Heils, S. Z. Sabol, B. D. Greenberg, S. Petri, J. Benjamin, C. R. Muller, D. H. Hamer, D. L. Murphy, Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region Science. ,vol. 274, pp. 1527- 1531 ,(1996) , 10.1126/SCIENCE.274.5292.1527
Courtney Shannon, Melanie L. Schwandt, Maribeth Champoux, Susan E. Shoaf, Stephen J. Suomi, Markku Linnoila, James D. Higley, Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. American Journal of Psychiatry. ,vol. 162, pp. 1658- 1664 ,(2005) , 10.1176/APPI.AJP.162.9.1658