The current understanding of sepsis and research priorities for the future.

摘要: This special issue of Virulence is entirely devoted to the topic sepsis and septic shock. Septic shock continues pose formidable challenges for emergency room physicians, critical care specialists, surgeons, infectious disease clinicians alike in caring these critically ill patients. Early recognition improved therapies manage multi-organ dysfunction that frequently follows pathophysiology remain major unmet medical needs. The interplay between virulence factors pathogen antimicrobial defenses host are determinants outcome shock.1 will specifically focus on both pathogen-related defense mechanisms lead contribute its resolution or fatal outcome. We have assembled a stellar group international experts field research compiled their ideas collective wisdom this issue. hope provide detailed review state art science as it currently exists, extending from molecular level population level.