CD151 in cancer progression and metastasis: a complex scenario

摘要: Originally identified as a molecular organizer of interacting proteins into tetraspanin-enriched microdomains, the tetraspanin CD151 has now been shown to be involved in tumour progression. Increasing evidence emerging from vitro, vivo and clinical analyses implicates this supporting growth various types tumours at different levels. It affects both cell autonomous behavior communication with neighboring cells microenvironment. regulates post-adhesion events, that is, spreading, migration invasion including subsequent intravasation formation metastasis. Present on neoplastic endothelial cells, is engaged promotion neovascularization. The mechanism cancer based its ability organize distribution function proteins, ie, laminin-binding integrins (α3β1, α6β1 α6β4), receptors for factors (HGFR, EGFR TGF-β1R) matrix metalloproteinases (MMP-7, MMP-2 MMP-9), which indicates importance disease development. Results expression large number models demonstrate impact implicate valuable diagnostic prognostic marker well potential target anti-cancer therapy.