Extended-release drug formulations for the treatment of epilepsy

摘要: INTRODUCTION Extended-release (ER) preparations are either available or have been tested for several antiepileptic drugs (AEDs). Indeed, they may be helpful in improving efficacy, tolerability, adherence, compared to the corresponding immediate release (IR) available. The use of ER has advocated women childbearing age and is - depending on drug especially patients who treated combination with enzyme inducing AEDs as well children. AREAS COVERED Clinical pharmacokinetic studies formulations were identified by a PubMed literature research. Further references added from authors' personal knowledge reference lists studies. Reviews expert commentaries included, where necessary. EXPERT OPINION Unfortunately, providing direct comparisons IR given only handful drugs. short elimination half-life concentration-depending efficacy tolerability.