Embryonic or Neural Stem Cells in Neurodegenerative Disease of the Central Nervous System (with Relevance to PD, HD, AD, MS, SCI, and Stroke)

作者: Stephen B. Dunnett , Cesar V. Borlongan , Paul R. Sanberg

DOI: 10.1002/9781118498453.CH17

关键词: Huntington's diseaseEmbryonic stem cellBrain damageNervous systemNeuroscienceNeural stem cellMedicineCentral nervous systemParkinson's diseaseMultiple sclerosis

摘要: There has been a recent dramatic increase in understanding how to replace neurons lost through aging, trauma or disease and repair brain damage with significant functional recovery variety of models human neurodegenerative disease. Donor factors identified various indicate that underlying successful cell transplantation the nervous system critically include harvesting at an appropriate stage notably embryonic neonatal development. Also necessary are nutritive environment for growth techniques implantation. Animal other have demonstrated potential feasibility using cells central disorders but present time clinical use such remains innovation development least part due complex precisely organized anatomical structures involved. also donor supply ethics issues conflicting trial work, however, clinicians working achieve consensus application evidence-based medicine.

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