Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care.
作者： Ronald J. Trent , Pak Leng Cheong , Eng Wee Chua , Martin A. Kennedy
DOI: 10.1097/PAT.0B013E328360B66E
关键词: Human genetic variation 、 Pharmacology 、 Identification (biology) 、 Efficacy 、 Pharmacogenetics 、 Bioinformatics 、 Genetic testing 、 Drug 、 Pharmacogenomics 、 Molecular diagnostics 、 Medicine
摘要: Summary Understanding human genetic variation and how it impacts on gene function is a major focus in genomic-based research. Translation of this knowledge into clinical care exemplified by pharmacogenetics/pharmacogenomics. The identification particular variants that might influence drug uptake, metabolism, distribution or excretion promises more effective personalised medicine approach choosing the right its dose for any individual. Adverse responses can then be avoided mitigated. An understanding germline acquired (somatic) DNA mutations also used to identify drugs are likely therapeutically beneficial. This represents an area growing interest treatment cancer.
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