Role of tissue factor in thrombosis in antiphospholipid antibody syndrome.

摘要: Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of antiphospholipid antibody (aPL) and occurrence at least one associated clinical condition that includes venous thrombosis, arterial thrombosis or pregnancy morbidity. The aPL detected in APS have long been thought to a direct prothrombotic effect vivo. However, pathophysiology underlying their coagulopathic has not defined. Emerging data suggest role for procoagulant protein tissue factor (TF). In this review we provide overview TF, describe mouse models used evaluation TF as well summarize recent work on APS.