Anatomy and pathogenesis of aorticopulmonary septal defect

摘要: The pathologic anatomic features and associated cardiac anomalies of 13 patients with aorticopulmonary septal defect (APSD) 236 previously reported cases were analyzed. Morphologically, 3 types APSD distinguished: a more or less circular border located about halfway between the arterial valves bifurcation pulmonary trunk; similarly in which represents helix; usually large there is no posterior (distal) border. appearance these defects suggests different developmental mechanism for each. Approximately half are not other cardiovascular anomalies. Of that do occur, anomalous origin coronary artery from trunk interruption aortic arch (IAA) type A severe preductal coarctation seen far often than expected. An association DiGeorge syndrome, frequently noted persistent truncus arteriosus (TA) IAA B, was seen. Certain TA rarely APSD, TA. These observations indicate pathogenetically unrelated even though same region heart and, unlike probably due to error involving neural crest.