Testosterone treatment of excessively tall boys.

摘要: Twenty-nine tall boys with a mean height prediction of 198 cm were treated for serious psychosocial reasons high doses long-acting testosterone preparation (500 mg/m 2 /month). Their ages at the start treatment ranged from 9.8 to 16.9 years, and duration was 1.2 years. Bone age assessed according Tanner-Whitehouse II (RUS) method, predictions calculated using age-specific regression equations Tanner colleagues. On basis bone treatment, three groups formed (bone 12.1 14, 14.1 15, >15 years), results separately. In whole series, adult reduced by 5.4 cm; best (8 cm) achieved in youngest group. Under maturation accelerated (1.8 years per year) growth velocity increased (youngest group) or normal (older groups). Testicular volume remained prepubertal young patients decreased older ones. After discontinuation testicular sperm count became again after period 1.5 but few cases recovery slower. It is concluded that may be effectively testosterone, are if started early puberty, suppressing effects on pituitary function fully reversible. Since indication one, should carefully selected, taking into account not only also psychological familial factors.