Profiles of metabolic control in diabetic children — Frequency of asymptomatic nocturnal hypoglycemia

摘要: Twenty-four hr glucose and hormonal monitoring was conducted in 34 randomly selected children with insulin dependent diabetes. Asymptomatic nocturnal hypoglycemia present 18% (634). The plasma decline of 20–25 mg/dl/hr reached a mean nadir 50 mg/dl. rebound hyperglycemia 300 mg/dl over the subsequent 6.4 hrs. significantly greater than any excursion diabetic daytime, symptomatic (n = 5) or those non-hypoglycemic profiles 23). Coincident decline, but preceeding nadir, marked release growth hormone which (p < .05) that observed other groups. This hormone, hypoglycemia, were reflected ratio awake/asleep concentrations hormone. These data support speculation contributes to hyperglycemic observed. Mean 24 varied considerably from patient such generalization for diabetes cannot be made. is frequent complication therapy Subsequent (the “Somogyi Effect”) associated exuberant counterregulatory precise pathophysiological role this unclear.