Reply to Rattay

摘要: reply: We thank Dr. Rattay (2014) for commenting on our work (Boinagrov et al. 2012) and exploring the nature of stimulation upper limit in a multi-compartmental model retinal ganglion cell (RGC), confirming sodium current reversal as mechanism this effect under certain conditions. are aware fact that threshold axonal hillock is lower than soma due to higher concentration ion channels area. have demonstrated previously transverse cellular polarization associated spherical cylindrical geometry similar characteristics 2010), therefore, can be described using same model, just with channels. On other hand, suppression propagating action potential (AP) hyperpolarized indeed beyond single-compartment was not considered study. As we state discussion, main distinction between roles depolarized membrane anodal surround block responsible prevention generation first place, while hyperpolarization compartments might prevent its propagation there. It would interesting check whether there (and what ranges of) experimental conditions where AP generated propagates into axon, but detected soma. This done, example, electrophysiological imaging high-density multielectrode arrays (Litke 2004). An alternative way discriminate these phenomena stimulate RGCs anodic pulses: should still outflow strong stimuli, no block.