In vitro percutaneous penetration and characterization of silver from silver-containing textiles.

摘要: The objective of this study was to determine the in vitro percutaneous penetration silver and characterize species released from textiles different layers full thickness human skin. For purpose, two wound dressings a garment soaked artificial sweat were placed donor compartments Franz cells for 24 hours. concentration phase skin determined by an electrothermal atomic absorption spectrometer (ET-AAS) inductively coupled plasma mass (ICP-MS). characterization made scanning electron microscopy with integrated energy dispersive X-ray spectroscopy (SEM-EDX). Additionally, size distribution nanoparticles performed force (AFM). On surface all investigated materials, morphology found. Released concentrations soaking solutions (ie, exposure concentration) ranged 0.7 4.7 μg/mL (0.6–4.0 μg/cm2), fitting bactericidal range. Silver chloride aggregates at sizes up 1 μm identified both epidermis dermis. large these particles suggests that aggregation occurred formation likely slowed down systemic silver. Conversely, may form reservoir enabling prolonged release ions, which might lead local effects.