Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

摘要: Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement specific epigenetic landmarks to impose ligand dependency gene activation remains unknown. Here we report unexpected and general strategy based on the cohorts of inhibitory histone methyltransferases (HMTs) gene-specific gatekeeper functions prevent unliganded nuclear other classes regulated transcription factors from binding their target promoters causing constitutive in absence stimulating signals. This strategy, at least part HMT-dependent code, imposes a demethylases, including LSD1, permit ligand- signal-dependent expression. These events link methylation component code broadly used circumvents pathological induction by physiologically factors.