Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain
作者： William Wisden , Brian J. Morris , Mark G. Darlison , Stephen P. Hunt , Eric A. Barnard
DOI: 10.1016/0896-6273(88)90151-1
关键词: Molecular biology 、 Cerebellum 、 Subiculum 、 GABAA receptor 、 Messenger RNA 、 Biology 、 Hippocampal formation 、 Entorhinal cortex 、 In situ hybridization 、 Dentate gyrus 、 General Neuroscience
摘要: Abstract Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of mRNAs encoding three structurally distinct GABA A receptor α subunits in bovine brain. In situ hybridization analysis showed that these transcripts differ relative abundance. frontal cortex α1 α2 are most abundant layers II–IV, whereas α3 mRNA is V VI. hippocampal complex, differentially distributed entorhinal subiculum. The transcript enriched dentate gyrus CA4CA3 regions hippocampus. cerebellum, essentially only detectable granule cells, Purkinje stellate/basket cells. These results suggest different represent components subtypes.
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