Camelina sativa Methanolic and Ethanolic Extract Potential in Alleviating Oxidative Stress, Memory Deficits, and Affective Impairments in Stress Exposure-Based Irritable Bowel Syndrome Mouse Models.

摘要: Camelina sativa is mainly used as an oilseed crop; its edible oil being also a traditional home remedy for the treatment of ulcers, wounds, and eye inflammations, due to antioxidant activities. In present study, chemically characterized alcoholic extracts var. Madalina defatted seeds (5 g/kg body weight p.o., suspended in CMC-Na 0.1%) were administered stress-induced animal models irritable bowel syndrome (based on combinations contention stress multifactorial maternal stress) evaluated behavioural (short-term memory by Y maze test, anxious behaviour using elevated plus antidepressant effect forced swimming test) brain tissue oxidative status (superoxide dismutase glutathione peroxidase enzymes activities malondialdehyde total soluble protein levels) improving effects. According chemical characterization, rich sinapine, glucosinolates, flavonol glycosides. Moreover, this study showed beneficial effects seed methanolic ethanolic tissues exposure-based IBS mouse models. Despite slight differences composition extracts, results suggested that could reverse short-term impairments caused exposure decrease intensity frequency anxiety depressive-like behaviours observed stress-exposed IBS. Furthermore, significant markers studied model decreasing superoxide activity increasing activity. However, increase lipid peroxidation tissues. way, provides additional evidence administration improve cognitive performances mood exhibit capacity both