Topical morphine for the treatment of cutaneous leishmaniasis.

摘要: Cutaneous leishmaniasis (CL) is a potentially disfiguring parasitic disease which endemic in many parts of the world. The evidence for optimal treatment CL uncongenial. development compound used topical an attractive option overcoming problems toxic and expensive currently anti-leishmanial drugs. Easy application another attraction compared to systemic therapy. Evidence certainly about variety immune responses healing process CL. modulatory effect morphine also has been known clinical medicine decades. Protection against dependent upon generation CD4(+) helper T-cells response. There are some evidences that opioids could be members cytokine family regulation inflammatory on functions cytokines; therefore much effort should placed understanding activity. Based previous mentioned we suggest as immunomodulator induce cutaneous through inducing release number cytokines.