β-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli

摘要: The role of combination antibiotic therapy with a beta-lactam and fluoroquinolone for bacteremia caused by gram-negative bacilli, to our knowledge, has not been previously described. Much the previous study included beta-lactams aminoglycosides. We conducted large retrospective cohort evaluate 28-day all-cause mortality in patients monomicrobial due aerobic bacilli who received either fluoroquinolones or monotherapy. enrolled adult admitted Mayo Clinic hospitals from 1 January 2001 31 October 2006 study. After stratification Pitt scores, we used Cox regression models estimate hazard ratios (HR) after adjusting propensity receive therapy. identified 398 304 unique single therapy, respectively. In less severely ill scores <4, was associated lower than (4.2% [9 214] versus 8.8% [28 319]; adjusted HR, 0.44; 95% confidence interval [CI], 0.20 0.98; P = 0.044). critically ≥4, there no difference between (25.6% [23 90] 27.8% [22 79]; 0.87; CI, 0.47 1.62; 0.660). These findings were consistent 14-day mortality. this cohort, found first time that reduction among bacilli.