Pathophysiology and treatment of cardiac amyloidosis

作者: Morie A. Gertz , Angela Dispenzieri , Taimur Sher

DOI: 10.1038/NRCARDIO.2014.165

关键词: CardiologyDiastoleHeart failurePathogenesisMedicineCardiac amyloidosisIschemiaInternal medicinePathologyPathophysiologyAmyloidosisCardiology and Cardiovascular Medicine

摘要: Amyloidosis is caused by the aggregation of insoluble fibrous deposits misfolded proteins. Cardiac deposition can lead to diastolic dysfunction, arrhythmias, and ischaemia. In this Review, Gertz et al. summarize pathophysiology condition, how best achieve early diagnosis treatment, before advanced heart failure occurs.

参考文章(133)
Victor H. Jimenez-Zepeda, Norman Franke, Donna E. Reece, Suzanne Trudel, Christine Chen, Diego H. Delgado, Andrew Winter, Joseph R. Mikhael, Rodger Tiedemann, Vishal Kukreti, Autologous stem cell transplant is an effective therapy for carefully selected patients with AL amyloidosis: experience of a single institution. British Journal of Haematology. ,vol. 164, pp. 722- 728 ,(2014) , 10.1111/BJH.12673
Rebecca T. Levinson, Oludare O. Olatoye, Edward G. Randles, Kyle G. Howell, Ara Celi DiCostanzo, Marina Ramirez-Alvarado, Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes Scientific Reports. ,vol. 3, pp. 1278- 1278 ,(2013) , 10.1038/SREP01278
Gillian C. Nesbitt, Sunil Mankad, Strain and Strain Rate Imaging in Cardiomyopathy Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. ,vol. 26, pp. 337- 344 ,(2009) , 10.1111/J.1540-8175.2008.00867.X
Chinami Miyazaki, Fletcher A. Miller, Diego Bellavia, Patricia A. Pellikka, Theodore P. Abraham, Ghormallah B. Al-Zahrani, Angela Dispenzieri, Jae K. Oh, Kent R. Bailey, Christina M. Wood, Martha Q. Lacy, Evidence of Impaired Left Ventricular Systolic Function by Doppler Myocardial Imaging in Patients With Systemic Amyloidosis and No Evidence of Cardiac Involvement by Standard Two-Dimensional and Doppler Echocardiography The American Journal of Cardiology. ,vol. 101, pp. 1039- 1045 ,(2008) , 10.1016/J.AMJCARD.2007.11.047
L A Sikkink, M Ramirez-Alvarado, Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture Cell Death and Disease. ,vol. 1, ,(2010) , 10.1038/CDDIS.2010.75
Maria João, Mascarenhas Saraiva, Transthyretin mutations in health and disease Human Mutation. ,vol. 5, pp. 191- 196 ,(1995) , 10.1002/HUMU.1380050302
Ghormallah B. Al-Zahrani, Diego Bellavia, Patricia A. Pellikka, Angela Dispenzieri, Suzanne R. Hayman, Jae K. Oh, Chinami Miyazaki, Fletcher A. Miller, Doppler Myocardial Imaging Compared to Standard Two-Dimensional and Doppler Echocardiography for Assessment of Diastolic Function in Patients With Systemic Amyloidosis Journal of the American Society of Echocardiography. ,vol. 22, pp. 290- 298 ,(2009) , 10.1016/J.ECHO.2008.11.013
Claudio Rapezzi, Letizia Riva, Cristina C. Quarta, Enrica Perugini, Fabrizio Salvi, Simone Longhi, Paolo Ciliberti, Francesca Pastorelli, Elena Biagini, Ornella Leone, Robin M. T. Cooke, Letizia Bacchi-Reggiani, Alessandra Ferlini, Michele Cavo, Giampaolo Merlini, Stefano Perlini, Sonia Pasquali, Angelo Branzi, Gender-related risk of myocardial involvement in systemic amyloidosis Amyloid. ,vol. 15, pp. 40- 48 ,(2008) , 10.1080/13506120701815373
Kirk P. Sloan, Charles J. Bruce, Jae K. Oh, Charanjit S. Rihal, Complications of Echocardiography-Guided Endomyocardial Biopsy Journal of the American Society of Echocardiography. ,vol. 22, pp. 324.e1- 324.e4 ,(2009) , 10.1016/J.ECHO.2008.12.023
Jian Guan, Shikha Mishra, Jianru Shi, Eva Plovie, Yiling Qiu, Xin Cao, Davide Gianni, Bingbing Jiang, Federica del Monte, Lawreen H. Connors, David C. Seldin, Francesca Lavatelli, Paola Rognoni, Giovanni Palladini, Giampaolo Merlini, Rodney H. Falk, Marc J. Semigran, G. William Dec, Calum A. MacRae, Ronglih Liao, Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Research in Cardiology. ,vol. 108, pp. 378- 378 ,(2013) , 10.1007/S00395-013-0378-5