Novel Chitosan-Derived Nanomaterials and Their Micelle-Forming Properties
作者： Can Zhang , Ya Ding , Qineng Ping , Liangli (Lucy) Yu
DOI: 10.1021/JF061541W
关键词: Nuclear chemistry 、 Organic chemistry 、 Alkyl 、 Differential scanning calorimetry 、 Chitosan 、 Particle size 、 Proton NMR 、 Dynamic light scattering 、 Nuclear magnetic resonance spectroscopy 、 Chemistry 、 Micelle
摘要: Six novel N-alkyl-N-dimethyl and N-alkyl-N-trimethyl chitosan derivatives were chemically synthesized characterized using FT-IR, 1H NMR, 13C differential scanning calorimetry (DSC), X-ray diffraction spectrometry (XRD). The alkyl groups included octyl (C8H17-), decanyl (C10H21-), lauryl (C12H25-). These also evaluated for their micelle-forming properties dynamic light scattering (DLS) transmission electron microscopy (TEM) techniques. All six capable of forming polymeric micelles in water with an average particle diameter ranging from 36 to 218 nm. Both N-octyl-N-dimethyl N-octyl-N-trimethyl formed nanomicelles under the experimental conditions, 36.0 52.5, respectively. length group N-trimethylation degree altered size micelles. To further understand effect N-alkyl substitution on micelles, additional five 8 58% prepared micelle sizes determined. results showed that was proportional N-octyl substitution. data suggest may form nanomicelles. Additional research is required investigate potential value-added utilization these controlled release targeted delivery hydrophobic bioactive food factors.
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sci-hub.se 参考文章(28)
A. Elizabeth Sloan, The Top 10 Functional Food Trends 2004 Food Technology. ,vol. 58, pp. 28- 51 ,(2004)
Paul Takhistov, Chithra P. Panchapakesan, Carmen I. Moraru, Carmen I. Moraru, Jozef L. Kokini, Qingrong Huang, Sean Liu, Nanotechnology: A New Frontier in Food Science Food Technology. ,vol. 57, pp. 24- 29 ,(2003)
Shohei Inoue, Yasuhisa Sakurai, Teruo Okano, Mizue Miyauchi, Kazunori Kataoka, Masayuki Yokoyama, Noriko Yamada, Characterization and Anticancer Activity of the Micelle-forming Polymeric Anticancer Drug Adriamycin-conjugated Poly(ethylene glycol)-Poly(aspartic acid) Block Copolymer Cancer Research. ,vol. 50, pp. 1693- 1700 ,(1990)
Fergus Clydesdale, Functional Foods: Opportunities & Challenges Food Technology. ,vol. 58, pp. 35- 40 ,(2004)
M.M Thanou, A.F Kotzé, T Scharringhausen, H.L Lueßen, A.G de Boer, J.C Verhoef, H.E Junginger, Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers. Journal of Controlled Release. ,vol. 64, pp. 15- 25 ,(2000) , 10.1016/S0168-3659(99)00131-5
Pham le Dung, Michel Milas, Marguerite Rinaudo, Jacques Desbrières, Water soluble derivatives obtained by controlled chemical modifications of chitosan Carbohydrate Polymers. ,vol. 24, pp. 209- 214 ,(1994) , 10.1016/0144-8617(94)90132-5
K. Kalyanasundaram, J. K. Thomas, Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems Journal of the American Chemical Society. ,vol. 99, pp. 2039- 2044 ,(1977) , 10.1021/JA00449A004
Mihail C Roco, Nanotechnology: convergence with modern biology and medicine. Current Opinion in Biotechnology. ,vol. 14, pp. 337- 346 ,(2003) , 10.1016/S0958-1669(03)00068-5
Kequan Zhou, Wenshui Xia, Can Zhang, Liangli (Lucy) Yu, In vitro binding of bile acids and triglycerides by selected chitosan preparations and their physico-chemical properties Lwt - Food Science and Technology. ,vol. 39, pp. 1087- 1092 ,(2006) , 10.1016/J.LWT.2005.07.009
Magdolna Bodnar, John F. Hartmann, Janos Borbely, Preparation and Characterization of Chitosan-Based Nanoparticles Biomacromolecules. ,vol. 6, pp. 2521- 2527 ,(2005) , 10.1021/BM0502258