Pathogenesis of Cyclosporin A-Induced Autoimmunity: Absence of T-cell Reactivity Towards Syngeneic Antigen Presenting Cells
作者： Jan G. M. C. Damoiseaux , Peter J. C. Van Breda Vriesman
DOI: 10.3109/08916939809008036
关键词: Antigen-presenting cell 、 Autoimmune disease 、 MHC class I 、 Syngeneic Bone Marrow Transplantation 、 Autoimmunity 、 Dendritic cell 、 Cyclosporin a 、 Antigen presentation 、 Immunology 、 Biology
摘要: Cyclosporin A-induced autoimmunity (CsA-AI) is a T-cell mediated inflammatory autoimmune disease of the skin resembling human scleroderma and often referred to as syngeneic-Graft-versus-Host Disease. Induction CsA-AI obtained by total body irradiation in combination with syngeneic bone marrow transplantation (BMT) subsequent administration CsA for 4 weeks; about 2 weeks after withdrawal develops. In CsA-AI, thought eliminate peripheral autoregula-tory T-cells, whereas interferes selection thymus giving rise putative autoreactive T-cells. MHC class II-self-peptide complexes have been function autoantigen(s). Moreover, induction used humans achieve Graft-versus-Leukemia effect based on this anti-MHC II reactivity. study we therefore examined whether T-cells rats respond dendritic cells (DC). Furthermore determined vitro stimulatory capacity presump...
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