Vitamin and mineral supplements: Friend or foe when combined with medications?
作者： Mark Donaldson , Riva Touger-Decker
关键词: Midazolam 、 Clinical trial 、 Intensive care medicine 、 Clarithromycin 、 Patient safety 、 Itraconazole 、 Vitamin 、 Dentistry 、 Medicine 、 Dietary Reference Intake 、 Adverse effect
摘要: ABSTRACT Background. Given the prevalence of vitamin and mineral supplement use among consumers potential for vitamin- mineral-drug interactions, as well oral systemic adverse effects excess consumption, health care providers (OHCPs) should ask all patients about their use. The challenges OHCPs are how to recognize manifestations these interactions safely manage while avoiding interactions. Methods. authors reviewed literature regarding between popular supplements medications used commonly in dentistry. They clinical databases decision support tools classify according level patient risk. address greatest concern with a high-quality evidence-based foundation either randomized controlled trials or meta-analyses. Conclusion. Most dentistry can be prescribed without regard However, taking anticoagulants cytochrome P450 3A4 substrates (such clarithromycin, erythromycin, ketoconazole, itraconazole, midazolam triazolam) addition specific (vitamins D, E, K, calcium, fluoride, iron, magnesium, selenium zinc) may face additional challenges. need know who receiving treatment combination therapies. Practical Implications. Recognition avoidance will help clinicians optimize emphasizing safety.
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