Site and Nature of Airway Obstruction in Chronic Obstructive Lung Disease

作者: James C. Hogg , Peter T. Macklem , W. M. Thurlbeck

DOI: 10.1056/NEJM196806202782501

关键词: MucusPathologyAirway obstructionMedicineAirway resistanceBronchographyCatheterNormal lungObstructive lung diseasePeripheral

摘要: We have wedged a small catheter in airways 2 to 3 mm in diameter in excised human lungs to have measure airway resistance central (R c ) and peripheral (R p ) to this site. In five …

参考文章(14)
P. T. Macklem, J. Mead, Resistance of central and peripheral airways measured by a retrograde catheter Journal of Applied Physiology. ,vol. 22, pp. 395- 401 ,(1967) , 10.1152/JAPPL.1967.22.3.395
W. Einthoven, Ueber die Wirkung der Bronchialmuskeln, nach einer neuen Methode untersucht, und über Asthma nervosum Pflüger, Archiv für die Gesammte Physiologie des Menschen und der Thiere. ,vol. 51, pp. 367- 445 ,(1892) , 10.1007/BF01671026
A.E. Anderson, Alvan G. Foraker, Relative dimensions of bronchioles and parenchymal spaces in lungs from normal subjects and emphysematous patients. The American Journal of Medicine. ,vol. 32, pp. 218- 226 ,(1962) , 10.1016/0002-9343(62)90291-7
Ewald R. Weibel, Morphometry of the Human Lung ,(2013)
Peter T. Macklem, Robert G. Fraser, William G. Brown, Bronchial Pressure Measurements in Emphysema and Bronchitis Journal of Clinical Investigation. ,vol. 44, pp. 897- 905 ,(1965) , 10.1172/JCI105206
Howard Dayman, Mechanics of airflow in health and in emphysema. Journal of Clinical Investigation. ,vol. 30, pp. 1175- 1190 ,(1951) , 10.1172/JCI102537
J. G. Leopold, J. Gough, Post-mortem Bronchography in the Study of Bronchitis and Emphysema Thorax. ,vol. 18, pp. 172- 177 ,(1963) , 10.1136/THX.18.2.172