CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
作者： Benjamin Goyer , Fátima Gebauer , Francois Houle , Martin J Simard , Tanit Guitart
DOI: 10.1038/S41388-021-01767-9
关键词: microRNA 、 Translation (biology) 、 Melanoma 、 Biology 、 Cell biology 、 Cold-shock domain 、 Gene silencing 、 Untranslated region 、 Metastasis
摘要: MicroRNAs and RNA-binding proteins (RBPs) primarily target the 3' UTR of mRNAs to control their translation stability. However, co-regulatory effects on specific in physiology disease are yet be fully explored. CSDE1 is an RBP that promotes metastasis melanoma mechanisms underlying its oncogenic activities need completely defined. Here we report interacts with miRNA-induced silencing complexes (miRISC) melanoma. We find association AGO2, essential component miRISC, which facilitated by depends first cold shock domain CSDE1. Both AGO2 bind PMEPA1. counters binding, leading increase PMEPA1 expression. also identify a miRNA, miR-129-5p, represses expression Collectively, our results show tumorigenic traits along miR-129-5p/AGO2 miRISC act antagonistically fine-tune toward progression
nature.com
sci-hub.st 参考文章(74)
Guillaume Jannot, Alejandro Vasquez-Rifo, Martin J. Simard, Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices. Methods of Molecular Biology. ,vol. 725, pp. 233- 249 ,(2011) , 10.1007/978-1-61779-046-1_16
Stefanie Jonas, Elisa Izaurralde, Towards a molecular understanding of microRNA-mediated gene silencing Nature Reviews Genetics. ,vol. 16, pp. 421- 433 ,(2015) , 10.1038/NRG3965
Marija Mihailovich, Cristina Militti, Toni Gabaldón, Fátima Gebauer, Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression. BioEssays. ,vol. 32, pp. 109- 118 ,(2010) , 10.1002/BIES.200900122
Thalia A Farazi, Jessica I Spitzer, Pavel Morozov, Thomas Tuschl, miRNAs in human cancer. The Journal of Pathology. ,vol. 223, pp. 102- 115 ,(2011) , 10.1002/PATH.2806
Linda Koch, Genomics: The best-laid plans of mice and men Nature Reviews Genetics. ,vol. 16, pp. 1- 1 ,(2015) , 10.1038/NRG3873
Marieke van Kouwenhove, Martijn Kedde, Reuven Agami, MicroRNA regulation by RNA-binding proteins and its implications for cancer Nature Reviews Cancer. ,vol. 11, pp. 644- 656 ,(2011) , 10.1038/NRC3107
Habiba Elatmani, Virginie Dormoy-Raclet, Pierre Dubus, François Dautry, Claire Chazaud, Hélène Jacquemin-Sablon, The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage. Stem Cells. ,vol. 29, pp. 1504- 1516 ,(2011) , 10.1002/STEM.712
Sigrid Cornelis, Sandrine A Tinton, Bert Schepens, Yanik Bruynooghe, Rudi Beyaert, UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein Nucleic Acids Research. ,vol. 33, pp. 3095- 3108 ,(2005) , 10.1093/NAR/GKI611
Suvendra N. Bhattacharyya, Regula Habermacher, Ursula Martine, Ellen I. Closs, Witold Filipowicz, Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress Cell. ,vol. 125, pp. 1111- 1124 ,(2006) , 10.1016/J.CELL.2006.04.031
Thanh Thao Vo Nguyen, Yukihide Watanabe, Aya Shiba, Masayuki Noguchi, Susumu Itoh, Mitsuyasu Kato, TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells Cancer Science. ,vol. 105, pp. 334- 341 ,(2014) , 10.1111/CAS.12355