Tumor and transplantation

作者: M. Guba , J. Andrassy , M. Angele , C. Bruns

DOI: 10.1007/S00104-012-2426-3

关键词: GynecologyHepatectomyTransplant surgeryMedicineCardiothoracic surgeryAbdominal surgeryNeoplasm RecurrenceTransplantationHemangioendothelioma

摘要: Tumortherapie und Transplantation, verbunden mit der zwangslaufig notwendigen Immunsuppression, scheinen unuberbruckbare Gegensatze zu sein. Die klinische Realitat zeigt jedoch, dass die Transplantation bei vielen primaren Lebertumoren im fruhen Stadium wohl effektivste Therapie darstellt. nach jeder notwendige Immunsuppression kann jedoch Bildung von Tumorrezidiven begunstigen. fuhrt auch einer deutlich erhohten Rate De-novo-Tumoren allen Transplantatempfangern. Aber langst nicht alle Immunsuppressiva haben den gleichen Effekt auf Tumoren. Klasse mTOR-Inhibitoren experimentellen, aber klinischen Setting, ausgepragte antitumorale Wirkungen empfiehlt sich so als Immunsuppressivum Wahl Patienten einem Tumorrisiko. Diese Ubersichtsarbeit soll wissenschaftlichen Hintergrund fur das Problem Tumoren darstellen.

参考文章(69)
Minoru Hojo, Takashi Morimoto, Mary Maluccio, Tomohiko Asano, Kengo Morimoto, Milagros Lagman, Toshikazu Shimbo, Manikkam Suthanthiran, Cyclosporine induces cancer progression by a cell-autonomous mechanism Nature. ,vol. 397, pp. 530- 534 ,(1999) , 10.1038/17401
K. Budde, F. Lehner, C. Sommerer, W. Arns, P. Reinke, U. Eisenberger, R. P. Wüthrich, S. Scheidl, C. May, E.-M. Paulus, A. Mühlfeld, H. H. Wolters, K. Pressmar, R. Stahl, O. Witzke, , Conversion From Cyclosporine to Everolimus at 4.5 Months Posttransplant: 3‐Year Results From the Randomized ZEUS Study American Journal of Transplantation. ,vol. 12, pp. 1528- 1540 ,(2012) , 10.1111/J.1600-6143.2012.03994.X
S. B. Campbell, R. Walker, S. See Tai, Q. Jiang, G. R. Russ, Randomized Controlled Trial of Sirolimus for Renal Transplant Recipients at High Risk for Nonmelanoma Skin Cancer American Journal of Transplantation. ,vol. 12, pp. 1146- 1156 ,(2012) , 10.1111/J.1600-6143.2012.04004.X
Markus Guba, Johann Pratschke, Christian Hugo, Bernhard K. Krämer, Andreas Pascher, Katharina Pressmar, Oliver Hakenberg, Michael Fischereder, Jens Brockmann, Joachim Andrassy, Bernhard Banas, Karl-Walter Jauch, , Early conversion to a sirolimus-based, calcineurin-inhibitor-free immunosuppression in the SMART trial: observational results at 24 and 36months after transplantation. Transplant International. ,vol. 25, pp. 416- 423 ,(2012) , 10.1111/J.1432-2277.2012.01432.X
Arno Kornberg, Bernadett Küpper, Andrea Tannapfel, Peter Büchler, Babette Krause, Ulrike Witt, Dietmar Gottschild, Helmut Friess, Patients with non–[18F]fludeoxyglucose‐avid advanced hepatocellular carcinoma on clinical staging may achieve long‐term recurrence‐free survival after liver transplantation Liver Transplantation. ,vol. 18, pp. 53- 61 ,(2012) , 10.1002/LT.22416
M. T van Leeuwen, A. C Webster, M. R E McCredie, J. H Stewart, S. P McDonald, J. Amin, J. M Kaldor, J. R Chapman, C. M Vajdic, A. E Grulich, Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort study BMJ. ,vol. 340, ,(2010) , 10.1136/BMJ.C570
Francesco P Schena, Michael D Pascoe, Josefina Alberu, Maria del Carmen Rial, Rainer Oberbauer, Daniel C Brennan, Josep M Campistol, Lorraine Racusen, Martin S Polinsky, Robert Goldberg-Alberts, Huihua Li, Joseph Scarola, John F Neylan, Sirolimus CONVERT Trial Study Group, Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation. ,vol. 87, pp. 233- 242 ,(2009) , 10.1097/TP.0B013E3181927A41
S. Huber, C.J. Bruns, G. Schmid, P.C. Hermann, C. Conrad, H. Niess, R. Huss, C. Graeb, K.-W. Jauch, C. Heeschen, M. Guba, Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis Kidney International. ,vol. 71, pp. 771- 777 ,(2007) , 10.1038/SJ.KI.5002112
Sylvie Euvrard, Emmanuel Morelon, Lionel Rostaing, Eric Goffin, Anabelle Brocard, Isabelle Tromme, Nilufer Broeders, Veronique del Marmol, Valérie Chatelet, Anne Dompmartin, Michèle Kessler, Andreas L. Serra, Günther F.L. Hofbauer, Claire Pouteil-Noble, Josep M. Campistol, Jean Kanitakis, Adeline S. Roux, Evelyne Decullier, Jacques Dantal, Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation The New England Journal of Medicine. ,vol. 367, pp. 329- 339 ,(2012) , 10.1056/NEJMOA1204166
Young-Ran Lee, In-Ho Yang, Young-Hee Lee, Sun-A Im, Sukgil Song, Hong Li, Kun Han, Kyungjae Kim, Seong Kug Eo, Chong-Kil Lee, Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells Blood. ,vol. 105, pp. 3951- 3955 ,(2005) , 10.1182/BLOOD-2004-10-3927