Effects of lipophilicity and functional groups of synthetic cannabinoids on their blood concentrations and urinary excretion
作者： Hidenao Kakehashi , Noriaki Shima , Akari Ishikawa , Atsushi Nitta , Ryutaro Asai
DOI: 10.1016/J.FORSCIINT.2019.110106
关键词: Synthetic cannabinoids 、 Valine 、 Urine 、 Octanol 、 Chemistry 、 Carboxamide 、 Lipophilicity 、 Partition coefficient 、 Chromatography 、 Pharmacokinetics
摘要: The influence of lipophilicity and functional groups synthetic cannabinoids (SCs) on their blood concentrations urinary excretion has been studied by analyzing urine specimens sampled from drivers who were involved in a car crashes under the SCs. A total 58 (26 31 specimens), within 13h occurrence, analyzed liquid chromatography-tandem mass spectrometry. Fifteen SCs detected those specimens; categorized as follows: Class 1, Naphthoyl/Benzoyl indole (EAM2201 three other analogs); 2, Indole-3-carboxylate/carboxamide containing naphthol/quinol (5F-PB-22 four 3, Indazole-3-carboxamide valine/tert-leucine derivative (5F-AMB five analogs). calculated index log P, octanol/water participation coefficient, Classes 3 ranged between 5.01-8.14, 5.80-6.74 2.29-3.81, respectively. detectable 12 out 13 specimens, but 1 2 not urine. Our analytical results indicated that boundary line for detectability lies P 4 5. varied widely (0.0036-31ng/ml) depending while much smaller variation was observed among (0.10-5.0ng/ml).
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