Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits.
作者： M. Medina , M. R. Alberto , L. Sierra , C. Van Nieuwenhove , S. Saad
DOI: 10.1007/S11745-014-3915-6
关键词: Arachidonic acid 、 Fatty acid 、 Lipid metabolism 、 Biology 、 Linoleic acid 、 Endothelial dysfunction 、 Internal medicine 、 Prostaglandin 、 Cholesterol 、 Nitric oxide 、 Endocrinology
摘要: The present study evaluated the plasma fatty acid levels and vascular prostaglandin (PG) release in a rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either control diet (CD) or containing 1 % cholesterol (HD) for 5–6 weeks. level acids was measured plasma. PG nitric oxide (NO) released from aorta also determined. Vascular morphology characterized by intima media thickness measurements. rabbits HD had higher arachidonic (ARA) lower oleic acid. linoleic unchanged. PGI2 NO diminished PGF2α levels, PGI2/TXA2 ratio intima/media increased HD. In conclusion, feeding short period ARA unbalanced vasodilator/vasoconstrictor redirected pathway to vasoconstrictor metabolite release. These lipid metabolism alterations addition reduced moderate changes contributed dysfunction this animal model. Therefore, findings support importance correction prevention high disrupt process that leads cardiovascular disease.
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