Interobserver reproducibility in the diagnosis of prostatic intraepithelial neoplasia

摘要: To assess interobserver reproducibility in the categorization of prostatic intraepithelial neoplasia (PIN) seven pathologists reviewed 25 lesions. Rather than classic or consecutive examples PIN, cases were selected to represent full spectrum diagnostic issues this field. Lesions classified into one six categories: (a) benign prostate tissue, (b) PIN1, (c) PIN2, (d) PIN3, (e) PIN3 cannot rule out associated cancer, and (f) plus cancer. Following evaluation slides, data also analyzed by combining several groups three benign/PIN1; PIN2/PIN3/PIN cancer; PIN The level agreement was fair (Kappa = 0.33) for categories substantial 0.61) groups. In no case there a uniform diagnosis PIN1; all at least some considered biopsies be normal. This finding provides support not commenting on PIN1 biopsy material. general, good distinction between low-grade (PIN1) high-grade (PIN2-3). Among which consensus that lesion represented as whether PIN2 PIN3. supports PIN. Cases others those with pleomorphism but without prominent nucleoli. Difficulties distinguishing "high-grade PIN" from "high grade cancer" cribriform glands, glands necrosis, where only few adjacent small atypical glands. These same histologies caused participating difficulty cancer."